Significance and meaning are closely related, but they are not the same thing.
Significance identifies what matters.
Meaning explains what what matters means.
A condition may be significant because it affects an organism’s persistence, functioning, or future possibilities. Food, danger, opportunities, and relationships can all be significant because they influence what happens next.
Meaning emerges when that significance is interpreted within broader frameworks of relation, consequence, value, purpose, identity, and understanding. Significance concerns relevance. Meaning concerns interpretation.
In APS:
Significance = What matters
Meaning = What what matters means