Information is not a substance.
Nor is it a thing that exists independently of living systems.
APS interprets information as organised difference that matters for continuity.
Most differences in the world have no biological significance for a particular organism. Information emerges only when a difference becomes capable of influencing viability-oriented organisation.
The value of information therefore depends upon the relationship between a difference, an organism, and the continuity-relevant conditions to which that difference refers.
Information acquires biological significance because living systems inhabit worlds structured by meaning.
It is organised difference operating within systems of organised persistence.