Predictive, inferential, informational, and computational processes become biologically meaningful only within systems that are already organised around viability-oriented persistence.

APS therefore reverses a common explanatory strategy.

Living systems do not persist because they predict.

Rather, predictive capacities arise within systems whose organisation already supports persistence.

Organised persistence is explanatorily prior to prediction.

The central biological question is not how prediction generates life, but how living organisation generates the conditions under which predictive and inferential processes can emerge and acquire biological significance.